Regulation of IκB Kinase Complex by Phosphorylation of γ-Binding Domain of IκB Kinase β by Polo-like Kinase 1*
نویسندگان
چکیده
منابع مشابه
Deconstructing IκB kinase
On page 1677, Ruocco et al. show that the formation of bone-resorbing osteoclasts is crippled when the  subunit of the NF- B–activating I B kinase (IKK) complex is missing. The absence of IKK  also protected mice against inflammatory-induced bone loss, a complication of inflammatory diseases such as rheumatoid arthritis (RA) that is caused by excessive activation of osteoclasts. The osteoc...
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of the NF-B dimer which then translocates to the nucleus to activate gene transcription. In the case of IB␣ the inducible phosphorylation sites were mapped to ser-ines (S) 32 and 36, whose substitution with alanines (A) or threonines (T) prevents phosphorylation, ubiquitination Summary was recognized that the key step in NF-B activation is IB phosphorylation, much of the effort to understan...
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The IκB kinase (IKK) complex is the signal integration hub for NF-κB activation. Composed of two serine-threonine kinases (IKKα and IKKβ) and the regulatory subunit NEMO (also known as IKKγ), the IKK complex integrates signals from all NF-κB activating stimuli to catalyze the phosphorylation of various IκB and NF-κB proteins, as well as of other substrates. Since the discovery of the IKK comple...
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Platelet secretion plays a key role in thrombosis, thus the platelet secretory machinery offers a unique target to modulate hemostasis. We report the regulation of platelet secretion via phosphorylation of SNAP-23 at Ser95. Phosphorylation of this t-soluble N-ethylmaleimide sensitive factor attachment protein receptor (SNARE) occurs upon activation of known elements of the platelet signaling ca...
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Nuclear factor (NF)-kappaB is a key regulator of synovial inflammation. We investigated the effect of local NF-kappaB inhibition in rat adjuvant arthritis (AA), using the specific IkappaB kinase (IKK)-beta blocking NF-kappaB essential modulator-binding domain (NBD) peptide. The effects of the NBD peptide on human fibroblast-like synoviocytes (FLS) and macrophages, as well as rheumatoid arthriti...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 2008
ISSN: 0021-9258
DOI: 10.1074/jbc.m806258200